Xanthine Oxidoreductase in Drug Metabolism: Beyond a Role as a Detoxifying Enzyme
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منابع مشابه
Xanthine Oxidoreductase in Drug Metabolism: Beyond a Role as a Detoxifying Enzyme
The enzyme xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism in the highest uricotelic primates. XOR is an enzyme with dehydrogenase activity that, in mammals, may be converted into oxidase activity under a variety of pathophysiologic conditions. XOR activity is highly regulated at the transcriptional and post-translational levels and may generate reactive oxygen a...
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Emerging evidence supports the importance of nitroso-redox balance in the cardiovascular system. Xanthine oxidoreductase (XOR) is a major oxidative enzyme and increased XOR activity, leading to both increased production of reactive oxygen species and uric acid, is implicated in heart failure. Within the heart, XOR activity stimulates cardiomyocyte hypertrophy, apoptosis, and impairs matrix stru...
متن کاملStudy of Drug Metabolism by Xanthine Oxidase
In this work, we report the studies of drug metabolism by xanthine oxidase (XOD) with electrochemical techniques. Firstly, a pair of stable, well-defined and quasi-reversible oxidation/reduction peaks is obtained with the formal potential at -413.1 mV (vs. SCE) after embedding XOD in salmon sperm DNA membrane on the surface of pyrolytic graphite electrode. Then, a new steady peak can be observe...
متن کاملHuman xanthine oxidoreductase: in search of a function.
The molybdoenzyme, xanthine oxidoreductase (XOR), has been much studied, largely because of its ready availability on a large scale from cows' milk [ l ] . It catalyses the oxidation of a wide range of substrates, most notably hypoxanthine and xanthine, generating xanthine and uric acid respectively, in the process of purine catabolism. The enzyme is a homodimer of 150 kDa subunits and exists i...
متن کاملXanthine oxidoreductase in cancer: more than a differentiation marker
Human xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism and is present in two interconvertible forms, which may utilize O2 or NAD(+) as electron acceptors. In addition to uric acid, XOR products may comprise reactive oxygen and nitrogen species that have many biologic effects, including inflammation, endothelial dysfunction, and cytotoxicity, as well as mutagenesis...
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ژورنال
عنوان ژورنال: Current Medicinal Chemistry
سال: 2016
ISSN: 0929-8673
DOI: 10.2174/0929867323666160725091915